Systematic control of protein interactions for systems biology
نویسندگان
چکیده
منابع مشابه
Systematic control of protein interactions for systems biology.
S ince its birth, systems biology has gained a great deal from the protocols devised to study phenomena at the level of single proteins and nucleic acids. Such protocols find broad markets and utility at higher levels of biological organization, from next-generation sequencing, which uses modified nucloeotides and fluorescent identifiers (1), to ChIP-seq analysis, which identifies histone modif...
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Advances in protein-protein interaction (PPI) detection technology and computational analysis methods have produced numerous PPI networks, whose completeness appears to depend on the extent of data derived from different PPI assay methods and the complexity of the studied organism. Despite the partial nature of human PPI networks, computational data integration and analyses helped to elucidate ...
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Although targeting protein-protein interfaces of regulatory multiprotein complexes has become a significant focus in drug discovery, it continues to pose major challenges. Most interfaces would be classed as 'undruggable' by conventional analyses, as they tend to be large, flat and featureless. Over the past decade, encouragement has come from the discovery of hotspots that contribute much of t...
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Finding new drug targets for pathogenic infections would be of great utility for humanity, as there is a large need to develop new drugs to fight infections due to the developing resistance and side effects of current treatments. Current drug targets for pathogen infections involve only a single protein. However, proteins rarely act in isolation, and the majority of biological processes occur v...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2011
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1118084109